Acebilustat(ZK322)

Cas No.:	943764-99-6
Chemical Name:	Acebilustat
Synonyms:	Acebilustat;4-[[(1S,4S)-5-[[4-[4-(2-Oxazolyl)phenoxy]phenyl]methyl]-2,5-diazabicyclo[2.2.1]hept-2-yl]methyl]benzoic acid;J64RI4D29U;4-(((1S,4S)-5-(4-(4-(oxazol-2-yl)phenoxy)benzyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)methyl)benzoic acid;Acebilustat [INN];Acebilustat(ZK322);Acebilustat [WHO-DD];BCP19611;DB15385;SB19003;Q27281250;4-[[(1S,4S)-2-[[4-[4-(1,3-oxazol-2-yl)phenoxy]phenyl]methyl]-2,5-diazabicyclo[2.2.1]heptan-5-yl]methyl]benzoic acid;Benzoic acid, 4-(((1S,4S)-5-((4-(4-(2-oxazolyl)phen
SMILES:	O(C1C([H])=C([H])C(C2=NC([H])=C([H])O2)=C([H])C=1[H])C1C([H])=C([H])C(=C([H])C=1[H])C([H])([H])N1C([H])([H])[C@]2([H])C([H])([H])[C@@]1([H])C([H])([H])N2C([H])([H])C1C([H])=C([H])C(C(=O)O[H])=C([H])C=1[H]
Formula:	C29H27N3O4
M.Wt:	481.5424
Purity:	>98%
Sotrage:	4°C for 1 year, -20°C for more than 2 years

Description:	Acebilustat is a leukotriene A4 hydrolase inhibitor, used for an oral antiinflammatory drug.
In Vitro:	Acebilustat is a leukotriene A4 hydrolase inhibitor, which is safe and well tolerated in phase 1 trial[1]. Acebilustat is an antiinflammatory drug in development for the treatment of CF and other diseases. It is a potent inhibitor of the enzyme leukotriene A4 hydrolase (LTA4H), which catalyzes the rate-limiting step in the formation of leukotriene B4 (LTB4), a potent chemoattractant and activator of inflammatory immune cells including neutrophils[2].
References:	[1]. Elborn JS, et al. Phase 1 Studies of Acebilustat: Biomarker Response and Safety in Patients with Cystic Fibrosis. Clin Transl Sci. 2016 Nov 2 [2]. Elborn JS, et al. Phase I Studies of Acebilustat: Pharmacokinetics, Pharmacodynamics, Food Effect, and CYP3A Induction. Clin Transl Sci. 2016 Oct 28.