Alda-1|cas 349438-38-|DC Chemicals

Cas No.:	349438-38-6
Chemical Name:	N-(1,3-Benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide
Synonyms:	N-(1,3-Benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide;Alda 1;Alda-1;Alda1;BXB;Oprea1_166989;MLS001206840;N-Benzo[1,3]dioxol-5-ylmethyl-2,6-dichloro-benzamide;Benzamide, N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichloro-;N-(benzo[d][1,3]dioxol-5-ylmethyl)-2,6-dichlorobenzamide;HMS2847P05;BCP17146;STK417030;s5800;SMR000518092;AK547763;ST085712;B5508;Q27166749;N-[(2H-1,3-be
SMILES:	ClC1C([H])=C([H])C([H])=C(C=1C(N([H])C([H])([H])C1C([H])=C([H])C2=C(C=1[H])OC([H])([H])O2)=O)Cl
Formula:	C₁₅H₁₁Cl₂NO₃
M.Wt:	324.1587
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Alda-1 is a potent ALDH2 agonist, which activates wild-type ALDH2 and restores near wild-type activity to ALDH2*2.

In Vivo:

Alda-1 treatment results in a significant decrease of 4-HNE-protein content in the plasma of apoE−/− mice. Alda-1 administration leads to a slight increase in gene expression related to neurogenesis (Nog), mitochondrial biogenesis (CYTB, ND1), and apoptosis (Bax, Gsk3b) in the Hp of apoE−/− mice. Alda-1 administration leads to 2 and 10 differentially expressed proteins in the FCx and Hp of apoE−/− mice, respectively[1]. Alda-1 (1.5 mg/kg, b.w., i.p.) administration significantly increases the climbing time, tends to reduce the immobility time and increases the swimming time of the prenatally stressed rats in the forced swim test. Moreover, treatment of prenatally stressed rats with Alda-1 significantly increases number of entries into the open arms of the maze and the time spent therein, as assessed by elevated plus-maze test[2]. Alda-1 (8.5 mg/kg, i.p.) with glucose significantly lowers 4-HNE and FJB-positive cells in the cerebral cortex of Alda-1-treated rats than in DMSO-treated rats 24 h after glucose administration[3]. Alda-1 (10 mg/kg per day) treatment prevents aldehydic overload, mitochondrial dysfunction and improves ventricular function in post-MI cardiomyopathy rats[4].

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

Cat. No.	Product name	Field of application
DC12128	NCT-505	NCT-505 is a potent and selective aldehyde dehydrogenase (ALDH1A1) inhibitor, with an IC50 of 7 nM, and weakly inhibits hALDH1A2, hALDH1A3, hALDH2, hALDH3A1 (IC50s, >57, 22.8, 20.1, >57 μM).
DC7391	CVT-10216	CVT-10216 is a potent and selective, reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) (IC50 values are 29 and 1300 nM for ALDH2 and ALDH1, respectively).
DC8723	Alda-1	Alda-1 is an ALDH2 agonist, cell-permeable activator of both the wild-type ALDH21 and the asian E487K mutant ALDH22 forms of mitochondrial aldehyde dehydrogenase 2 (mtALDH2).