BIX02189（BIX 02189）cas 1094614-85-3|supplier DC Chemicals

Cas No.:	1265916-41-3
Chemical Name:	(Z)-3-(((3-((dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide
Synonyms:	BIX 02189,BIX02189
SMILES:	O=C(N(C)C)C1=CC(NC2=O)=C(/C2=C(C3=CC=CC=C3)/NC4=CC=CC(CN(C)C)=C4)C=C1
Formula:	C₂₇H₂₈N₄O₂
M.Wt:	440.54
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

BIX 02189 is a selective MEK5/ERK5 inhibitor with an IC50 of 59 nM. BIX02189 was reported to inhibit catalytic function of purified, MEK5 enzyme.For the detailed information of BIX02189 （BIX 02189）, the solubility of BIX02189 （BIX 02189） in water, the solubility of BIX02189 （BIX 02189） in DMSO, the solubility of BIX02189 （BIX 02189） in PBS buffer, the animal experiment (test) of BIX02189 （BIX 02189）, the cell expriment (test) of BIX02189 （BIX 02189）, the in vivo, in vitro and clinical trial test of BIX02189 （BIX 02189）, the EC50, IC50,and Affinity of BIX02189 （BIX 02189）, Please contact DC Chemicals.

MSDS

COA

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2018-0101

Cat. No.	Product name	Field of application
DC47575	MEK4 inhibitor-2	MEK4 inhibitor-2 is a novel MEK4 inhibitor against pancreatic adenocarcinoma with an IC50 value of 83 nM.
DC47574	MEK4 inhibitor-1	MEK4 inhibitor-1 is a novel MEK4 inhibitor against pancreatic adenocarcinoma with an IC50 value of 61 nM.
DC47263	Zapnometinib	Zapnometinib (PD0184264), an active metabolite of CI-1040, is a MEK inhibitor, with an IC50 of 5.7 nM. Zapnometinib exhibits antiviral activity against influenza virus and antibacterial activities.
DC40562	PD0325901-O-C2-dioxolane	PD0325901-O-C2-dioxolane has main portion of MEK inhibitor PD0325901. PD0325901-O-C2-dioxolane and a ligand of VHL or CRBN E3 ligase can be used in the synthesis of MEK1/2 degrader.
DC29029	Selumetinib sulfate	Selumetinib (AZD6244) is selective, non-ATP-competitive oral MEK1/2 inhibitor, with an IC50 of 14 nM for MEK1. Selumetinib (AZD6244) inhibits ERK1/2 phosphorylation.
DC5003	BIX02189 (BIX 02189）	BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.

BIX02189 (BIX 02189）