Bisindolylmaleimide X(Ro 31-8425)

  Cat. No.:  DC10052   Featured
Chemical Structure
1241725-89-2
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Field of application
Bisindolylmaleimide X is a cell-permeable, reversible, ATP-competitive protein kinase C (PKC) inhibitor (IC50 = 15 nM, rat brain PKC).
Cas No.: 1241725-89-2
Chemical Name: 3-​[8-​(aminomethyl)-​6,​7,​8,​9-​tetrahydropyrido[1,​2-​a]indol-​10-​yl]-​4-​(1-​methyl-​1H-​indol-​3-​yl)-​1H-​pyrrole-​2,​5-​dione,​ monohydrochloride
Synonyms: BIM X,Ro 31-8425 Ro 31-8425
SMILES: CN1C2=CC=CC=C2C=C1C3=C(C(=O)NC3=O)C4=C5CC(CCN5C6=CC=CC=C64)CN
Formula: C26H24N4O2
M.Wt: 424.49
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Bisindolylmaleimide X is a cell-permeable, reversible, ATP-competitive protein kinase C (PKC) inhibitor (IC50 = 15 nM, rat brain PKC).
In Vitro: Bisindolylmaleimide X is a cell-permeable, reversible, ATP-competitive protein kinase C (PKC) inhibitor (IC50?= 15 nM, rat brain PKC).It has been shown to inhibit PKCα, βI, βII, γ, and ε with IC50?values of 8, 8, 14, 13, and 39 nM, respectively. It has also been identified as an inhibitor of Cdk2 (IC50?= 200 nM) and GSK3α/β. This compound has been used to activate mesenchymal stem cells, increase the surface expression of homing ligands that bind to intercellular adhesion molecule, and target delivery of these cells to sites of inflammation
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
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