CA4948-Analog
Cat. No.: DC10648
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Chemical Structure
1801343-74-7
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Field of application
CA4948-Analog is an analog of Emavusertib. It has similar property to CA-4948, which is a potent, and orally active interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor. It was reported in patent WO 2015104688. Emavusertib, also known as CA-4948 i
| Cas No.: |
1801343-74-7 |
| Chemical Name: |
N-(1-(6'-amino-[2,3'-bipyridin]-5-yl)vinyl)-2-morpholinooxazolo[4,5-c]pyridin-6-amine |
| Synonyms: |
CA-4948; CA 4948; CA4948 |
| SMILES: |
O=C(C1=CC=CC(C2=CC=C(N)N=C2)=N1)NC3=CN=C4C(OC(N5CCOCC5)=N4)=C3 |
| Formula: |
C21H19N7O3 |
| M.Wt: |
417.42 |
| Sotrage: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
CA-4948 is a selective and potent IRAK4 inhibitor. |
| In Vivo: |
CA-4948 is a selective and potent IRAK4 inhibitor which can be used as a therapeutic agent for hematological cancers with dysregulated TLR/MYD88/IRAK4 signaling. CA-4948 exhibits favorable DMPK properties, oral bioavailability, and is well tolerated in mice. Furthermore, CA-4948 is previously shown to exhibit dose-dependent efficacy in ABC-DLBCL MYD88-L265P xenograft tumor models[1]. |
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