C-DIM12

Cas No.:	178946-89-9
Chemical Name:	3,3'-[(4-chlorophenyl)methylene]bis-1H-Indole
Synonyms:	3,3'-[(4-chlorophenyl)methylene]bis-1H-Indole;C-DIM12;C-DIM-12;3,3′-[(4-Chlorophenyl)methylene]bis-1H-indole;4-Chlorophenyldi-3-indolylmethane;4-Chlorophenyl-3,3′-diindolylmethane;C-DIMI2;C-DIM12(1,1-bis (3'-indolyl)-1-(p-chlorophenyl) methane);CDIM12;3,3'-((4-chlorophenyl)methylene)bis(1H-indole);3-[(4-chlorophenyl)-(1H-indol-3-yl)methyl]-1H-indole;DIM-C-pPhCl;3,3'-[(4-Chlorophenyl)methylene]bis[1H-indole];3,3'-[(4-chlorophenyl)methylene]bis(1h-indole);BCP17151;STK687745;s8097;AK546309;3,3'-(4-Chlorobenzylidene)di(1H-indole);3,3'-[(4-chlorophenyl)methylene]bis-1H-;1H-Indole, 3,3'-[(4-chlorophenyl)methylene]bis-;3,3'-(4-Chlorobenzylidene)di;4-Chlorophenyl-3,3'-diindolylmethane;1,1-Bis(3-indolyl)-1-(4-chlorophenyl)methane;C-DIM 12;ethyl (E)-3-diethylaminoprop-2-enoate;http:////www.amadischem.com/proen/561635/;Not available
SMILES:	ClC1C=CC(C(C2=CNC3=CC=CC=C23)C2=CNC3=CC=CC=C23)=CC=1
Formula:	C23H17ClN2
M.Wt:	356.847484350204
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

C-DIM12 is a synthetic Nurr1 activaor induces Nurr1 and DA gene expression in cell lines and primary neurons.Target: Nurr1in vitro: C-DIM12 as a modulator of Nurr1 activity that results in inhibition of NF-κB-dependent gene expression in glial cells by stabilizing nuclear corepressor proteins, which reduces binding of p65 to inflammatory gene promoters. C-DIM12 Decreases Inflammatory Gene Expression in BV-2 Microglia. C-DIM12 Decreases Expression of NF-κB-Enhanced GFP Expression in Human Embryonic Kidney 293 Reporter Cells.[1] C-DIM12 increases protein levels of exogenously expressed human Nurr1 in transfected neurons.C-DIM12 protects neurons from 6-hydroxydopamine toxicity. [2]

References:

[1]. De Miranda BR, et al. The Nurr1 Activator 1,1-Bis(3'-Indolyl)-1-(p-Chlorophenyl)Methane Blocks Inflammatory Gene Expression in BV-2 Microglial Cells by Inhibiting Nuclear Factor κB. Mol Pharmacol. 2015 Jun;87(6):1021-34. doi: 10.1124/mol.114.095398. Epub [2]. Hammond SL, et al. A novel synthetic activator of Nurr1 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro. Neurosci Lett. 2015 Oct 21;607:83-9.