Cabazitaxel

Cas No.:	183133-96-2
Chemical Name:	Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano
Synonyms:	XRP-6258
SMILES:	C[C@]1(C([C@@H]2OC)=O)[C@@H]([C@@]3(OC(C)=O)[C@H](OC3)C[C@@H]1OC)[C@H](OC(c4ccccc4)=O)[C@]5(O)C[C@H](OC([C@H](O)[C@H](c6ccccc6)NC(OC(C)(C)C)=O)=O)C(C)=C2C5(C)C
Formula:	C45H57NO14
M.Wt:	835.93
Purity:	99%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Description of Cabazitaxel: Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel binds to and stabilizes tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, this agent is a poor substrate For the membrane-associated, multidrug resistance (MDR), P-glycoprotein (P-gp) efflux pump and may be useful For treating multidrug-resistant tumors. In addition, cabazitaxel penetrates the blood-brain barrier (BBB). Check For active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). For the detailed information about the solubility of Cabazitaxel in water, the solubility of Cabazitaxel in DMSO, the solubility of Cabazitaxel in PBS buffer, the animal experiment（test） of Cabazitaxel, the in vivo,in vitro and clinical trial test of Cabazitaxel, the cell experiment（test） of Cabazitaxel, the IC50, EC50 and Affinity of Cabazitaxel , please contact DC Chemicals.