Cas No.: | 51781-21-6 |
Synonyms: | Carteolol (hydrochloride);NSC 300906;OPC 1085 |
SMILES: | O=C1CCC2=C(OCC(CNC(C)(C)C)O)C=CC=C2N1.Cl |
Formula: | C16H24N2O3.HCl |
M.Wt: | 328.8 |
Purity: | >98% |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | Carteolol is an antagonist of β-adrenergic receptors (Kd = 13 nM).It blocks isoproterenol-induced increases in heart rate, contractile force, and blood pressure in vagotomized dogs (ED50s = 2.3, 3.1, and 1.8 µg/kg, respectively).The (R) and (S)-enantiomers of carteolol reduce intraocular pressure to similar levels in rabbits when applied topically as a 1% solution.Formulations containing carteolol have been used in the treatment of open-angle glaucoma. |