Centrinone-B| Plk4 inhibitor|cas 1798871-31-4

Cas No.:	1798871-31-4
SMILES:	CC1=CC(=NN1)NC2=NC(=NC(=C2OC)N3CCCCC3)SC4=C(C=C(C=C4)S(=O)(=O)CC5=C(C(=CC=C5)[N+](=O)[O-])F)F
Formula:	C₂₇H₂₇F₂N₇O₅S₂
M.Wt:	631.67
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Centrinone-B is a high affinity and selective PLK4 inhibitor (Ki = 0.59 nM). Centrinone-B is a selective and reversible inhibitor of polo-like kinase 4 (Plk4). Centrinone-B exhibits >2000-fold selectivity for PLK4 over Aurora A and Aurora B.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC73219	Allopole	Allopole is the first allosteric, specfic and cell-permeable inhibitor of the noncatalytic polo-box domain (PBD) of PLK1 (Polo-like kinase 1), Allopole is the prodrug of Allopole-A.
DC70300	CFI-400945	CFI-400945 is a potent, highly selective PLK4 inhibitor with Ki of 0.26 nM and IC50 of 2.8 nM, does not significantly inhibits PLK1/2/3 at 50 uM; causes dysregulated centriole duplication, mitotic defects, and cell death in multiple cancer cell lines (A549 GI50=5 nM, OVCAR-3 GI50=18 nM); significantly inhibits human cancer xenografts; causes polyploidy, growth inhibition, and apoptotic death of murine and human lung cancer cells, despite expression of mutated KRAS or p53, produces supernumerary centrosomes and mitotic defects in lung cancer cells.
DC8598	PLK1 inhibitor GSK461364	GSK461364 is a potent small molecule Polo-like kinase 1 (PLK1) inhibitor with a Ki of 2.2 nM.
DC7187	Volasertib(BI6727)	Volasertib(BI6727) is a highly potent PLK1 inhibitor with an IC50 of 0.87 nM; shows 6- and 65-fold greater selectivity against Plk2 and Plk3.
DC7265	Rigosertib	Rigosertib (ON-01910) is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM; shows 30-fold greater selectivity against PLK2 and no activity to PLK3.
DC9594	Poloxin	Poloxin is a non-ATP competitive Polo-like Kinase 1 (PLK1) inhibitor that targets the polo-box domain.
DC8768	HMN-214	HMN-214(IVX214) is a potent PLK1 inhibitor an average IC50 of 0.12 μM.
DC8609	GW843682X	GW843682X is a cell-permeable thiophene-benzimidazole compound and reversible PLK inhibitor
DC10011	Centrinone-B	Centrinone-B is a high affinity and selective PLK4 inhibitor (Ki = 0.59 nM).
DC7083	Bi 2536	BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM, BI2536 shows 4- and 11-fold greater selectivity against Plk2 and Plk3; BI2536 also is a BRD4 inhibitor(IC50= 25 nM).