Chloroquine diphosphate|cas 50-63-5|DC Chemicals

Cas No.:	50-63-5
Chemical Name:	N4-(7-chloroquinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine bis(phosphate)
Synonyms:	Chloroquine phosphate, Chloroquine diphosphate; Chloroquine; Alermine; Aralen; Aralen diphosphate; Aralen phosphate; Arechin; Avloclor; Bemaphate; Chingamin; Chingamin phosphate; Chingaminum; Chlorochin diphosphate; Chloroquin diphosphate; Chloroquine dih
SMILES:	ClC1C=CC2C(=CC=NC=2C=1)NC(C)CCCN(CC)CC.P(O)(O)(O)=O.P(O)(O)(O)=O
Formula:	C₁₈H₃₂ClN₃O₈P₂
M.Wt:	515.8645
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Chloroquine diphosphate is an antimalarial drug and autophagy/lysosome inhibitor; inhibits Toll-like receptor (TLR) signalling in plasmacytoid dendritic cells (pDCs).in vitro: CHQ-treated MoLC promoted IL-17A secretion by CD4(+) T cells and elevated RORC mRNA levels, whereas IFN-γ release was reduced. The dysregulation of IL-12 family cytokines in MoLC and MoDC occurred at the transcriptional level. CQ was well tolerated and all patients maintained an undetectable VL. The absolute CD4 and CD8 T-cell counts and their percentages, the pDC proportion, T-cell activation, D-dimer and C-reactive protein (CRP) plasma levels and the kynurenine/tryptophan ratio did not change with CQ treatment. Among nine cytokines/chemokines measured, only levels of interferon (IFN)-α2 were significantly increased by CQ treatment. Chloroquine suppressed matrix metalloproteinase (MMP)-2 and MMP-9 mRNA expression and protein activity, whereas MMP-13 mRNA expression and proteolytic activity were increased. Despite enhancing TLR9 mRNA expression, chloroquine suppressed TLR9 protein expression in vitro. in vivo: Daily treatment of mice with intraperitoneal (i.p.) chloroquine (80 mg/kg/day) for 22 days, did not inhibit the growth of control siRNA or TLR9 siRNA MDA-MB-231 breast cancer cells . Proliferation of HuH7 cells in vitro increased significantly in response to stimulation of TLR7. TLR7 and TLR9 inhibition using IRS-954 or chloroquine significantly reduced HuH7 cell proliferation in vitro and inhibited tumour growth in the mouse xenograft model.

MSDS

COA

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2018-0101

Cat. No.	Product name	Field of application
DC9169	Chloroquine diphosphate	Chloroquine diphosphate is an antimalarial drug and autophagy/lysosome inhibitor; inhibits Toll-like receptor (TLR) signalling in plasmacytoid dendritic cells (pDCs).