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Chroman 1 dihydrochloride

  Cat. No.:  DC41080  
Chemical Structure
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Field of application
Chroman 1 dihydrochloride is a highly potent ROCK2 inhibitor, with an IC50 of 1 nM. Chroman 1 dihydrochloride also shows inhibitory activities against MRCK, with an IC50 of 150 nM.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.:
Chemical Name: Chroman 1 dihydrochloride
SMILES: O=C([C@@H]1COC2=CC=C(OC)C=C2C1)NC3=CC=C(C4=CNN=C4)C=C3OCCN(C)C.Cl.Cl
Formula: C24H30Cl2N4O4
M.Wt: 509.43
Sotrage: Please store the product under the recommended conditions in the Certificate of Analysis.
MSDS
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COA
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Cat. No. Product name Field of application
DC46829 Cotosudil Cotosudil is a ROCK kinase inhibitor, which can be used for glaucoma or ocular hypertension research.
DC46480 RKI-1447 dihydrochloride RKI 1447 dihydrochloride is a potent and selective ROCK inhibitor with IC50s of 14.5 and 6.2 nM for ROCK1 and ROCK2, respectively. RKI 1447 dihydrochloride suppresses colorectal carcinoma cell growth and promotes apoptosis.
DC46167 Sovesudil Sovesudil, formally known as PHP-201, is a well-tolerated and low toxicity Rho-associated protein kinase (ROCK) inhibitor. Sovesudil can be used for the research of normal-tension glaucoma (NTG).
DC45269 H-1152 dihydrochloride H-1152 dihydrochloride (2HCl) is a membrane-permeable and selective inhibitor of Rho-associated protein kinase (ROCK). H-1152 inhibits ROCK2, PKA, PKC, PKG, AuroraA and CaMK2 with IC50 of 0.0120 μM, 3.03 μM, 5.68 μM, 0.360 μM, 0.745 μM and 0.180 μM, respectively.
DC41914 Exoenzyme C3, clostridium botulinum Exoenzyme C3, clostridium botulinum is a promising agent to inactivate RhoA in neurons due to preventing the detrimental effect of active Rho in the recovery of injured neuronal systems. Exoenzyme C3, clostridium botulinum is used for the study of post-traumatic neuro-regeneration.
DC41080 Chroman 1 dihydrochloride Chroman 1 dihydrochloride is a highly potent ROCK2 inhibitor, with an IC50 of 1 nM. Chroman 1 dihydrochloride also shows inhibitory activities against MRCK, with an IC50 of 150 nM.
DC8104 SAR407899 HCl SAR407899 Hcl is a potent, ATP-competitive ROCK inhibitor woth Ki value of 36 nM/41 nM for human ROCK/Rat ROCK respectively.
DC12203 Pentanoic acid Pentanoic acid, a short-chain fatty acid, is a product of bacterial metabolism and are associated with allergic skin disorders. Pentanoic acid activates ROCK signaling pathway.
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