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| Cas No.: | 153259-65-5 |
| Synonyms: | SB-207499;Ariflo;SB207499;SB 207499 |
| SMILES: | N#C[C@@]1(CC[C@H](C(O)=O)CC1)C2=CC=C(OC)C(OC3CCCC3)=C2 |
| Formula: | C20H25NO4 |
| M.Wt: | 343.4168 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | Cilomilast(SB 207499; Ariflo) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. Cilomilast (SB-207499) inhibits HPDE4 and LPDE4 catalytic activity with equal potency (Ki ≈100 nM). SB-207499 and rolipram are equipotent against LPDE4, but Cilomilast (Ariflo, SB-207499) is 100-fold less potent against HPDE4. This profile suggests that Cilomilast (Ariflo, SB-207499) retain the anti-inflammatory activity of rolipram yet have a decreased tendency to produce side effects. |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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