MDK19922| NOD-IN-1|Compound 4|cas 132819-92-2

Cas No.:	132819-92-2
Chemical Name:	ethyl 1-tosyl-1H-indole-2-carboxylate
Synonyms:	NOD-IN-1, compound 4; MDK19922; MDK 19922; MDK-19922.
SMILES:	CCOC(=O)c1cc2ccccc2n1S(=O)(=O)c1ccc(C)cc1
Formula:	C₁₈H₁₇NO₄S
M.Wt:	343.4
Sotrage:	4°C for 1 year, -20°C for more than 2 years

Description:

NOD-IN-1 is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors, NOD1 and NOD2, with IC50 of 5.74 μM and 6.45 μM, respectively.

In Vitro:

NOD-IN-1 (compound 4) is potent mixed inhibitor of NOD1 and NOD2, displaying a balanced inhibitory activity on both targets in the low micromolar range. NOD-IN-1 (IC50 (NOD1)=5.74 μM; IC50 (NOD2)=6.45 μM) is identified as the best of the series, possessing NOD1- and NOD2-inhibitory activities in the lower micromolar range. These results show that NOD-IN-1 is 7-fold less potent than Noditinib-1 in terms of NOD1 inhibition and completely devoid of selective activity for NOD1 or NOD2 as opposed to Noditinib-1. NOD-IN-1 exhibits balanced dual activities of less than 10 μM on the two targets[1].

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

Cat. No.	Product name	Field of application
DC9254	MCC950 (CP-456773) sodium	MCC950 (CP-456773) sodium is a potent, selective, small-molecule inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs.
DC9930	NOD-IN-1	NOD-IN-1 is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors, NOD1 and NOD2, with IC50 of 5.74 μM and 6.45 μM, respectively.
DC10142	ML130	ML-130 is a potent and selective inhibitor of NOD1; displays 36-fold selectivity for NOD1 over NOD2 (IC50 values are 0.56 and >20 μM for NOD1 and NOD2 respectively).
DC10483	INF39	INF39 is an irreversible and noncytotoxic NLRP3 inhibitor.
DC10620	CY-09	CY-09 is an NLRP3 inhibitor.