Crisaborole(AN-2728)|cas 906673-24-3|DC Chemicals

Cas No.:	906673-24-3
Chemical Name:	Crisaborole
Synonyms:	4-((1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)oxy)benzonitrile;AN-2728;4-((1-Hydroxy-1,3-dihydrobenzo-[c][1,2]oxaborol-5-yl)oxy)benzonitrile;4-[(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]Benzonitrile;5-(4-CYANOPHENOXY)-2,3-DIHYDRO-1-HYDROXY-2,1-BENZOXABOROLE;AN 2728;Crisaborole;5-(4-Cyanophenoxy)-1,3-dihydro-1-hydroxy-[2,1]-benzoxaborole;AN2728;Eucrisa;Crisaborole topical ointment 2%;Crisaborole (AN2728);Q2R47HGR7P;AK102641;4-[(1-hydroxy-3H-2,1-benzoxaborol-5-yl)oxy]benzonitrile;4-[(1-hydroxy-1,3-dihydr;4-[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-5-
SMILES:	O1B(C2C([H])=C([H])C(=C([H])C=2C1([H])[H])OC1C([H])=C([H])C(C#N)=C([H])C=1[H])O[H]
Formula:	C₁₄H₁₀BNO₃
M.Wt:	251.0451
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

AN-2728 is a topically administered, boron-containing, anti-inflammatory compound that inhibits PDE4 activity and thereby suppresses the release of TNFalpha, IL-12, IL-23 and other cytokines. AN-2728 appears to have good therapeutic potential, although further and larger trials are required to assess the long-term safety and characterize the broad utility of this drug. AN-2728 shows potent activity both in vitro and in vivo. AN-2728 is now in clinical development for the topical treatment of psoriasis and being pursued for the topical treatment of atopic dermatitis.For the detailed information of AN-2728, the solubility of AN-2728 in water, the solubility of AN-2728 in DMSO, the solubility of AN-2728 in PBS buffer, the animal experiment (test) of AN-2728, the cell expriment (test) of AN-2728, the in vivo, in vitro and clinical trial test of AN-2728, the EC50, IC50,and affinity,of AN-2728, Please contact DC Chemicals.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

Cat. No.	Product name	Field of application
DC10141	E6005	E6005 potently and selectively inhibited human PDE4 activity with an IC50 of 2.8 nM and suppressed the production of various cytokines from human lymphocytes and monocytes with IC50 values ranging from 0.49 to 3.1 nM.
DC7815	Crisaborole(AN-2728)	AN-2728 is a topically administered, boron-containing, anti-inflammatory compound that inhibits PDE4 activity and thereby suppresses the release of TNFalpha, IL-12, IL-23 and other cytokines.