DB550|DB-550;DB 550

Cas No.:
Chemical Name:	(S)-2-(N-((5S,11S,17S,18R)-5-((1H-imidazol-4-yl)methyl)-17-amino-6-(6-aminohexanoyl)-11-(3-guanidinopropyl)-18-hydroxy-12-(3-mercaptopropanoyl)-4,10,16-trioxo-3,6,9,12,15-pentaazanonadecyl)-5-guanidinopentanamido)heptanamide
Synonyms:	DB-550;DB 550
SMILES:	C(N)(=O)[C@H](N(CCNC(=O)[C@@H](CC1=CNC=N1)N(C(=O)CCCCCN)CCNC(=O)[C@@H](CCCNC(N)=N)N(C(=O)CCS)CCNC(=O)[C@H](N)[C@@H](O)C)C(=O)CCCCNC(N)=N)CCCCC
Formula:	C₄₄H₈₃N₁₇O₈S
M.Wt:	1010.319
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

DB550 (DB-550) is a potent, peptidomimetic of calcium-inducing domain (CID) that disrupts the CD95-PLCγ1 interaction without affecting the CD95-FADD interaction binds to SH3-PLCγ1 with Kd of 40.7 uM; abrogates the binding of PLCγ1 to CD95 in cells exposed to s-CD95L, inhibits the CD95-mediated Ca2+ response in a similar manner in Th17 cells to minCID and preventes Th17 trafficking across endothelial cells, does not affect the CD95-mediated apoptotic signaling pathway; abrogates the CD95-mediated Ca2+ response in mouse PBLs with IC50 of 68 nM, alleviates clinical symptoms in lupus-prone mice.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC47250	Nonanal	Nonanal is a saturated fatty aldehyde with antidiarrhoeal activity.
DC47249	Piperitone	Piperitone is as a powerful repellent and antiappetent agent. Piperitone is very toxic to Cymbopogon schoenanthus (C. schoenanthus) adults, newly laid eggs and to neonate larvae. Insecticidal activity.
DC47247	Tyrosylleucine TFA	Tyrosylleucine (Tyr-Leu, YL) TFA, an orally active dipeptide, exhibits a potent antidepressant-like activity.
DC47243	Dehydroglyasperin C	Dehydroglyasperin C, a isoflavone, is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C has antioxidant, neuroprotective, cancer chemopreventive, and anti-inflammatory activities.
DC47227	(−)-Myrtenal	(−)-Myrtenal ((1R)-(−)-Myrtenal) is an orally active terpene with antitumour activity. (−)-Myrtenal ameliorates hyperglycemia by enhancing GLUT2 through Akt in the skeletal muscle and liver of diabetic rats.
DC47224	GPX4-IN-3	GPX4-IN-3 (26a) is a potent glutathione peroxidase 4 (GPX4) inhibitor as a selective ferroptosis inducer. GPX4-IN-3 (26a) exhibits 71.7% inhibition for GPX4 with 1 μM.
DC47179	Tyrosylleucine	Tyrosylleucine (Tyr-Leu, YL), an orally active dipeptide, exhibits a potent antidepressant-like activity.
DC47178	Mead acid	Mead acid (5,8,11-Eicosatrienoic acid), an unsaturated (Omega-9) fatty acid, is an indicator of essential fatty acid deficiency.
DC47140	Yadanzioside K	Yadanzioside K is a natural quassinoid glucoside found in Brucea amarissima.
DC47105	Complanatoside B	Complanatoside B is a P. chinense Fisch flavonoid with potential anti-inflammatory effects.