MC3343

Cas No.:	1535187-91-7
Chemical Name:	N-[3-[(2-Amino-6-methylpyrimidin-4-yl)amino]phenyl]-3-(quinolin-4-ylamino)benzamide
Synonyms:	MC3343;BDBM50448484;N-(3-((2-Amino-6-methylpyrimidin-4-yl)amino)phenyl)-3-(quinolin-4-ylamino)benzamide;N-(3-(2-amino-6-methylpyrimidin-4-ylamino)phenyl)-3-(quinolin-4-ylamino)benzamide;N-[3-[(2-Amino-6-methylpyrimidin-4-yl)amino]phenyl]-3-(quinolin-4-ylamino)benzamide
SMILES:	O=C(C1C([H])=C([H])C([H])=C(C=1[H])N([H])C1=C([H])C([H])=NC2=C([H])C([H])=C([H])C([H])=C12)N([H])C1=C([H])C([H])=C([H])C(=C1[H])N([H])C1C([H])=C(C([H])([H])[H])N=C(N([H])[H])N=1
Formula:	C27H23N7O
M.Wt:	461.5178
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

MC3343 (MC-3343) is a novel potent, non-nucleoside DNA methyltransferase (DNMT) inhibitor with IC50 of 5.7 and 1.7 uM for DNMT1 and DNMT3a in cell-free assays, respectively; displays increased potency against DNMT1 compared with RG-108 and SGI-1027; efficiently inhibits OS cell proliferation and induces osteoblastic differentiation, induces dose- and time-dependent decreases in DNMT1, DNMT3a and DNMT3b protein levels in Saos-2 OS cells; displays synergistic effects with doxorubicin and cisplatin in vivo, reduces patient-derived xenograft OS growth and induces differentiation.

References:

References 1. Manara MC, et al. Mol Cancer Ther. 2018 Jun 29. pii: molcanther.0818.2017. View Related Products by Target DNA Methyltransferase (DNMT).