YW3-56|

Cas No.:	1374311-17-7
Chemical Name:	(S)-N-(1-(benzylamino)-5-(2-chloroacetimidamido)-1-oxopentan-2-yl)-6-(dimethylamino)-2-naphthamide
SMILES:	C1=C2C(C=C(N(C)C)C=C2)=CC=C1C(N[C@H](CCCNC(=N)CCl)C(NCC1=CC=CC=C1)=O)=O
Formula:	C₂₇H₃₂ClN₅O₂
M.Wt:	494.036
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

YW3-56 is a potent peptidylarginine deiminase (PAD) inhibitor with inhibitory activity against PAD2 (IC50=0.5-1 uM) and PAD4 (IC50=1-2 uM), inhibits U2OS cancer cell growth with IC50 of 2.5 uM; activates a cohort of p53 target genes, including SESN2, which in turn inhibits the mTORC1 signaling pathway, thereby perturbing autophagy and inhibiting cancerous cell growth, effectively inhibits the growth of triple-negative breast cancer xenograft tumors in nude mice; also significantly blocks LPS-induced pulmonary vascular leakage, alleviates acute lung injury, and improves survival in mouse model of lethal LPS-induced endotoxemia.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC47357	D-Cl-amidine hydrochloride	D-Cl-amidine hydrochloride is a potent and highly selective PAD1 inhibitor. D-Cl-amidine is well-torelated with no significant toxicity.
DC10999	YW3-56	YW3-56 is a potent peptidylarginine deiminase (PAD) inhibitor with inhibitory activity against PAD2 (IC50=0.5-1 uM) and PAD4 (IC50=1-2 uM), inhibits U2OS cancer cell growth with IC50 of 2.5 uM.