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| Cas No.: | 1850385-64-6 |
| Chemical Name: | (S)-2-(7-Fluoro-4-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-3-yl)-N-methylacetamide |
| Synonyms: | AZD 9977;AZD-9977 |
| SMILES: | C(NC)(=O)C[C@@H]1COC2=CC(F)=CC=C2N1C(C1=CC=C2C(=C1)NC(=O)CO2)=O |
| Formula: | C20H18FN3O5 |
| M.Wt: | 399.378 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Publication: | 1. Bamberg K, et al. PLoS One. 2018 Feb 23;13(2):e0193380. 2. Erlandsson F, et al. Br J Clin Pharmacol. 2018 Feb 21. doi: 10.1111/bcp.13562. |
| Description: | AZD9977 is a novel, first-in-class, selective and oral mineralocorticoid receptor (MR) modulator with pKi of 7.5, shows little to no affitnity for GR, PR and AR (pIC50<5.5); dose dependently reduces albuminuria and improves kidney histopathology similar to eplerenone in db/db uni-nephrectomised mice and uni-nephrectomised rats, does not affect urinary Na+/K+ ratio. Diabetes Phase 1 Clinical |
| References: | References 1. Bamberg K, et al. PLoS One. 2018 Feb 23;13(2):e0193380. 2. Erlandsson F, et al. Br J Clin Pharmacol. 2018 Feb 21. doi: 10.1111/bcp.13562. View Related Products by Target Mineralocorticoid Receptor (MLR) Diabetes |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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| 2018-0101 |
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| 2018-0101 |
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