AZD9977
Cat. No.: DC11032
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Chemical Structure
1850385-64-6
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Field of application
AZD9977 is a first-in-class, potent, selective, mineralocorticoid receptor (MR) modulator with IC50 of 0.37. 0.08 and 0.08 uM for human, mouse and rat MR, respectively.
| Cas No.: |
1850385-64-6 |
| Chemical Name: |
(S)-2-(7-Fluoro-4-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-3-yl)-N-methylacetamide |
| Synonyms: |
AZD 9977;AZD-9977 |
| SMILES: |
C(NC)(=O)C[C@@H]1COC2=CC(F)=CC=C2N1C(C1=CC=C2C(=C1)NC(=O)CO2)=O |
| Formula: |
C20H18FN3O5 |
| M.Wt: |
399.378 |
| Purity: |
>98% |
| Sotrage: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Publication: |
1. Bamberg K, et al. PLoS One. 2018 Feb 23;13(2):e0193380.
2. Erlandsson F, et al. Br J Clin Pharmacol. 2018 Feb 21. doi: 10.1111/bcp.13562. |
| Description: |
AZD9977 is a novel, first-in-class, selective and oral mineralocorticoid receptor (MR) modulator with pKi of 7.5, shows little to no affitnity for GR, PR and AR (pIC50<5.5); dose dependently reduces albuminuria and improves kidney histopathology similar to eplerenone in db/db uni-nephrectomised mice and uni-nephrectomised rats, does not affect urinary Na+/K+ ratio. Diabetes Phase 1 Clinical |
| References: |
References 1. Bamberg K, et al. PLoS One. 2018 Feb 23;13(2):e0193380. 2. Erlandsson F, et al. Br J Clin Pharmacol. 2018 Feb 21. doi: 10.1111/bcp.13562. View Related Products by Target Mineralocorticoid Receptor (MLR) Diabetes |
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