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QCA276

  Cat. No.:  DC11041  
Chemical Structure
2126819-40-5
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More than 5000 active chemicals with high quality for research!
Field of application
QCA276 is a novel potent BET proteins inhibitor with IC50/Ki of 10/.3 nM, QCA276 is the BET ligand for PROTAC QCA570.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2126819-40-5
Chemical Name: 3-Benzyl-9-methyl-2-((1-methyl-1H-pyrazol-4-yl)ethynyl)-4H,6Hthieno[2,3-e][1,2,4]triazolo[3,4-c][1,4]oxazepine
Synonyms: QCA 276;QCA-276
SMILES: O1CC2C(CC3=CC=CC=C3)=C(C#CC3=CN(C)N=C3)SC=2N2C(C)=NN=C2C1
Formula: C22H19N5Os
M.Wt: 401.488
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: QCA276 is a novel potent BET proteins inhibitor with IC50/Ki of 10/.3 nM, QCA276 is the BET ligand for PROTAC QCA570; effectively inhibits human BRD2, BRD3, and BRD4 BD1 and BD2 proteins with Ki of 2-20 nM.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC10190 TPOP146 TPOP146 is a selective CBP/P300 benzoxazepine bromodomain inhibitor with Kd values of 134 nM and 5.02 μM for CBP and BRD4.
DC11041 QCA276 QCA276 is a novel potent BET proteins inhibitor with IC50/Ki of 10/.3 nM, QCA276 is the BET ligand for PROTAC QCA570.
DC12248 PROTAC BET degrader-2 PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins with an IC50 value of 9.6 nM in cell growth inhibition in the RS4;11 cells and capable of achieving tumor regression.
DC11063 MS645 MS645 (MS-645) is a novel, bivalent bromodomain (BRD) inhibitor with Ki of 18.4 nM for tandem BD1-BD2 (BRD4 BD1/BD2 ), shows12- to 28-fold gain in affinity for binding to the tandem BD1-BD2 over the single BD1 or BD2.
DC12313 GNE-371 GNE-371 is a potent and selective chemical probe for the second bromodomains of human transcription-initiation-factor TFIID subunit 1 and transcription-initiation-factor TFIID subunit 1-like, with an IC50 of 10 nM for TAF1(2).
DC9934 GNE-272 GNE-272 is a in Vivo Probe for the Bromodomains of CBP/EP300.
DC8556 BET-BAY 002 BET-BAY 002 is a potent BET inhibitor; shows efficacy in a multiple myeloma model.
DC11042 BET inhibitor CF53 BET inhibitor CF53 is a highly potent, orally active inhibitor of bromodomain and extra-terminal (BET) with Ki of <1 nM (BRD4 BD1).
DC7854 BAZ2-ICR BAZ2-ICR is a selective BAZ2 bromodomain inhibitor (Kd values are 109 and 170 nM for BAZ2A and BAZ2B respectively).
DC11568 HJB-97 A potent BET bromodomian inhibitor with IC50 of 3-7 nM for BRD2/3/4 BD1 and BD2..
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