E7107|E-7107

Cas No.:	630100-90-2
Chemical Name:	[(2S,3S,4E,6S,7R,10R)-7,10-Dihydroxy-2-[(2E,4E,6R)-6-hydroxy-7-[(2R,3R)-3-[(2R,3S)-3-hydroxypentan-2-yl]oxiran-2-yl]-6-methylhepta-2,4-dien-2-yl]-3,7-dimethyl-12-oxo-1-oxacyclododec-4-en-6-yl] 4-cycloheptylpiperazine-1-carboxylate
Synonyms:	E-7107
SMILES:	N(C(O[C@H]1[C@](O)(C)CC[C@H](O)CC(=O)O[C@@H](/C(=C/C=C/[C@](O)(C)C[C@H]2[C@H]([C@H]([C@H](O)CC)C)O2)/C)[C@H](C)C=C1)=O)1CCN(C2CCCCCC2)CC1
Formula:	C₄₀H₆₆N₂O₉
M.Wt:	718.97
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

E7107 (E-7107) is a derivative of pladienolide that targets the SF3b subunit of the spliceosome, shows significant antitumor activity in vitro and in vivo; E7107 blocks spliceosome assembly by preventing tight binding of U2 snRNP to pre-mRNA, has no apparent effect on U2 snRNP integrity.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC11062	E7107	E7107 (E-7107) is a derivative of pladienolide that targets the SF3b subunit of the spliceosome, shows significant antitumor activity in vitro and in vivo.