Ampreloxetine
Cat. No.: DC11076
Chemical Structure
1227056-84-9
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Field of application
Ampreloxetine (TD-9855) is a potent monoamine reuptake inhibitor with pIC50 of 8.0, 8.6 and 6.8 for human NET, SERT, and DAT, respectively.
| Cas No.: |
1227056-84-9 |
| Chemical Name: |
4-{2-[(2,4,6-trifluorophenoxy)methyl]phenyl}piperidine |
| Synonyms: |
TD-9855;TD9855 |
| SMILES: |
N1CCC(C2=CC=CC=C2COC2=C(F)C=C(F)C=C2F)CC1 |
| Formula: |
C18H18F3NO |
| M.Wt: |
321.343 |
| Purity: |
>98% |
| Sotrage: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
Ampreloxetine (TD-9855) is a potent monoamine reuptake inhibitor with pIC50 of 8.0, 8.6 and 6.8 for human NET, SERT, and DAT, respectively; displays an inhibitory selectivity of 4- to 10-fold for NE at human and rat transporter; engaged norepinephrine transporters (NET) and serotonin transporters (SERT) in rat spinal cord, with a plasma EC50 of 11.7 ng/mL and 50.8 ng/mL, respectively; TD-9855 is an investigational dual norepinephrine (NE) and serotonin (5-HT) reuptake inhibitor with selectivity for NE over 5-HT (NSRI). |
MSDS
COA
| LOT NO. |
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| 2018-0101 |
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