JPI-289
Cat. No.: DC11080
Chemical Structure
1449233-60-6
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Field of application
JPI-289 (JPI289) is a novel potent, water soluble PARP-1 inhibitor with IC50 of 18.5 nM, inhibits cellular PAR formation with IC50 of 10.7 nM.
| Cas No.: |
1449233-60-6 |
| Chemical Name: |
10-ethoxy-8-(morpholinomethyl)-2,3,4,6-tetrahydrobenzo[h][1,6]naphthyridin-5(1H)-one dihydrochloride dihydrate |
| Synonyms: |
JPI289 |
| SMILES: |
N1C2=C(C(=O)NC3=CC(CN4CCOCC4)=CC(OCC)=C32)CCC1.[H]Cl.[H]Cl.[H]O[H].[H]O[H] |
| Formula: |
C19H31Cl2N3O5 |
| M.Wt: |
452.373 |
| Purity: |
>98% |
| Sotrage: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
JPI-289 (JPI289) is a novel potent, water soluble PARP-1 inhibitor with IC50 of 18.5 nM, inhibits cellular PAR formation with IC50 of 10.7 nM; does not affect cell viability up to 1 mM in rat cortical neuronal cells; attenuates PARP activity restores ATP and NAD+ levels in oxygen glucose deprived (OGD) rat cortical neurons, reduces apoptosis-associated molecules such as apoptosis inducing factor (AIF), cytochrome C and cleaved caspase-3 in the OGD model; JPI-289 is a potential neuroprotective agent which could be useful as a treatment for acute ischaemic stroke. |
MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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