| Cas No.: | 1188371-47-2 |
| Chemical Name: | (2S)-2-amino-3-methyl-N-{4-[3-(1H-1,2,4-triazol-1-yl)-4-(3,4,5-trimethoxybenzoyl)phenyl]-1,3-thiazol-2-yl}butanamide |
| Synonyms: | Valecobulin;CKD516 |
| SMILES: | C(NC1=NC(C2=CC=C(C(=O)C3=CC(OC)=C(OC)C(OC)=C3)C(N3C=NC=N3)=C2)=CS1)(=O)[C@H](N)C(C)C |
| Formula: | C26H28N6O5S |
| M.Wt: | 536.607 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | CKD-516 (Valecobulin, CKD516) is a potent beta-tubulin polymerization inhibitor with marked antitumor activity both in vitro and in vivo; demonstrates potent cytotoxicity against several cancer cells including P-gp overexpressing MDR positive cell line (HCT15), also induces cell cycle arrest at G(2)/M phase, which is associated with strong inhibition of tubulin polymerization; shows antitumor efficacy against both murine tumors (CT26 and 3LL) and human xenogratfs (HCT116 and HCT15) in mice. |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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