TCH-165|TCH165|CAS 1446350-60-2|DC Chemicals

Cas No.:	1446350-60-2
Chemical Name:	ethyl (4R,5R)-1-benzyl-5-(4-(benzylamino)phenyl)-2-(4-methoxyphenyl)-4-phenyl-4,5-dihydro-1H-imidazole-4-carboxylate
Synonyms:	TCH165
SMILES:	C(C1=CC=C(OC)C=C1)1N(CC2=CC=CC=C2)[C@@H](C2=CC=C(NCC3=CC=CC=C3)C=C2)[C@@](C2=CC=CC=C2)(C(OCC)=O)N=1
Formula:	C₃₉H₃₇N₃O₃
M.Wt:	595.743
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	1. Njomen E, et al. Biochemistry. 2018 Jul 17;57(28):4214-4224. 2. Azevedo LM, et al. J Med Chem. 2013 Jul 25;56(14):5974-8.

Description:

TCH-165 is a specific small molecule modulator of proteasome assembly, regulates the dynamic equilibrium between the 20S and 26S proteasome complexes, favoring 20S-mediated protein degradation; enhances the degradation of both α-syn and tau, does not induce the degradation of GAPDH, enhances the degradation of intrinsically disordered proteins in cell culture; display a decrease in assembled 26S and an increase in 20S proteasome in treated cells.

References:

References 1. Njomen E, et al. Biochemistry. 2018 Jul 17;57(28):4214-4224. 2. Azevedo LM, et al. J Med Chem. 2013 Jul 25;56(14):5974-8. View Related Products by Target Proteasome

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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