| Cas No.: | 922050-57-5 |
| Chemical Name: | 2-((1-(3-chlorophenyl)-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)thio)acetonitrile |
| Synonyms: | Pim-DAPK3 inhibitor HS56 |
| SMILES: | C(#N)CSC1NC(=O)C2C=NN(C3=CC=CC(Cl)=C3)C=2N=1 |
| Formula: | C13H8ClN5Os |
| M.Wt: | 317.751 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | HS56 (Pim-DAPK3 inhibitor HS56) is a potent, dual Pim/DAPK3 inhibitor with Ki of 72 nM (Pim-3) and 315 nM (DAPK3), shows micromolar potency toward Pim-1 and Pim-2 (Ki=1.5 and 17 uM); displays a high degree of selectivity for DAPKs and Pims against a panel of 468 kinases, with only two off-target interactions TYK2 and GAK; also displays no significant inhibition or activation of nicotinic, adrenergic, or muscarinic receptors at 10 uM; HS56 delayed force onset, decreased contractile force, and reduced LC20 phosphorylation in excised rat caudal arterial VSM tissues, lowers blood pressure in spontaneously hypertensive mice without affecting heart rate. |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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