| Cas No.: | |
| Chemical Name: | Sodium (R)-4-(1-(6-(4-(trifluoromethyl)benzyl)-6-azaspiro[2.5]octane-5-carboxamido)cyclopropyl)benzoate |
| Synonyms: | CR 6086;CR-6086 |
| SMILES: | [Na+].C([O-])(=O)C1=CC=C(C(NC([C@H]2N(CC3=CC=C(C(F)(F)F)C=C3)CCC3(CC3)C2)=O)2CC2)C=C1 |
| Formula: | C26H26F3N2NaO3 |
| M.Wt: | 494.49 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | CR6086 (CR-6086) is a potent, selective prostaglandin E2 receptor 4 (EP4) antagonist with Ki of 16.6 nM (hEP4 receptor), inhibits PGE2-stimulated cAMP production with IC50 of 22 nM; reduces key cytokine players of RA (IL-6 and VEGF expression in macrophages, IL-23 release from dendritic cells, IL-17 release from Th17 cells) in models of human immune cells in culture; significantly improves all features of arthritis: severity, histology, inflammation and pain in CIA models of RA in rats and mice; CR6086 is better than the selective COX-2 inhibitor rofecoxib and at least as effective as the JAK inhibitor tofacitinib. |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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