AST-3424
Cat. No.: DC11163
Featured
Chemical Structure
2097713-68-1
We are official vendor of:
More than 5000 active chemicals with high quality for research!
Field of application
AST-3424 (OBI-3424, TH-3424) is a first-in-class, novel prodrug that selectively targets cancers overexpressing the enzyme AKR1C3, OBI-3424 is a highly selective prodrug that is converted by AKR1C3 to a DNA alkylating agent.
| Cas No.: |
2097713-68-1 |
| Chemical Name: |
OBI-3424 |
| Synonyms: |
3-[5-[(1S)-1-[Bis(aziridin-1-yl)phosphoryloxy]ethyl]-2-nitrophenoxy]-N,N-dimethylbenzamide;(1R)-1-{3-[3-(Dimethylcarbamoyl)phenoxy]-4-nitrophenyl}ethyl bis(1-aziridinyl)phosphinate;OBI-3424 |
| SMILES: |
P(N1CC1)(N1CC1)(=O)O[C@@H](C)C1C=CC(=C(C=1)OC1C=CC=C(C(N(C)C)=O)C=1)[N+](=O)[O-] |
| Formula: |
C21H25N4O6P |
| M.Wt: |
460.420165777206 |
| Purity: |
>98% |
| Sotrage: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
AST-3424 (OBI-3424, TH-3424) is a first-in-class, novel prodrug that selectively targets cancers overexpressing the enzyme AKR1C3, OBI-3424 is a highly selective prodrug that is converted by AKR1C3 to a DNA alkylating agent; OBI-3424 is a nitro-benzene prodrug of N,N’-bisethylenephosphoramidate, demonstrates in vivo efficacy against preclinical xenograft models of pediatric T-ALL. |
MSDS
COA
| LOT NO. |
DOWNLOAD |
|
|
| 2018-0101 |
|
Get Quote
