LV-320|LV320;LV 320

Cas No.:
Chemical Name:	(E)-3-(((4-(2-(7-chloroquinolin-4-yl)vinyl)phenyl)(phenethylthio)methyl)thio)propanoic acid
Synonyms:	LV320;LV 320
SMILES:	C(O)(=O)CCSC(C1=CC=C(/C=C/C2C3C(N=CC=2)=CC(Cl)=CC=3)C=C1)SCCC1=CC=CC=C1
Formula:	C₂₉H₂₆ClNO₂S₂
M.Wt:	520.102
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

LV-320 (LV320) is a novel potent, cell-active, allosteric inhibitor of the autophagy-related cysteine protease ATG4B with IC50 of 24.5 uM in ATG4B cleavage assays; LV-320 binds to ATG4B and is an uncompetitive inhibitor of ATG4B with Kd of 16 uM; blocks starvation-induced autophagic fux in vitro; also inhibit ATG4A with an IC50 of 35.5 uM, but does not shows meaningful inhibition for caspase-3 or cathepsin B; LV-320 reduces autophagic fux in vitro and is bioavailable and active in vivo, LV-320 is a relevant chemical tool to study the various roles of ATG4B in cancer and other contexts.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC11255	S130	S130 (ATG4B inhibitor S130) is a potent, specific ATG4B inhibitor with IC50 of 3.24 uM, shows strong affinity (Kd=4 uM) and specifically suppresses the activity of ATG4B, but not other proteases.
DC11172	LV-320	LV-320 (LV320) is a novel potent, cell-active, allosteric inhibitor of the autophagy-related cysteine protease ATG4B with IC50 of 24.5 uM in ATG4B cleavage assays.