Chemical Structure
1398496-82-6
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Field of application
S44819 (S 44819, Egis-13529) is a novel potent, competitive, selective antagonist of the α5-GABAAR with Kd of 221 nM, IC50 of 585 nM (α5β2γ2).
| Cas No.: |
1398496-82-6 |
| Chemical Name: |
5-(4-Fluoro-1-benzothiophen-2-yl)-8-methyl-1,9-dihydro2H-[1,3]oxazolo[4,5-H][2,3]benzodiazepin-2-one |
| Synonyms: |
S 44819;Egis-13529 |
| SMILES: |
C(C1SC2=CC=CC(F)=C2C=1)1C2=CC3OC(=O)NC=3C=C2CC(C)=NN=1 |
| Formula: |
C19H12FN3O2S |
| M.Wt: |
365.382 |
| Purity: |
>98% |
| Sotrage: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
S44819 (S 44819, Egis-13529) is a novel potent, competitive, selective antagonist of the α5-GABAAR with Kd of 221 nM, IC50 of 585 nM (α5β2γ2); does not inhibit the activation of α5-GABAARs by etomidate, displays week activity against α1β2γ2 (IC50=2.4 uM) and α3β2γ2 (IC50=3.7 uM); enhances hippocampal synaptic plasticity and exhibits pro-cognitive efficacy in vivo. |
MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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