JTT-551|JTT551;JTT 551

Cas No.:	776309-04-7
Chemical Name:	N-((5-(tert-butyl)thiazol-2-yl)methyl)-N-((4-(4-((4-(heptan-4-yl)phenoxy)methyl)phenyl)thiazol-2-yl)methyl)glycine
Synonyms:	JTT551;JTT 551
SMILES:	C(O)(=O)CN(CC1=NC=C(C(C)(C)C)S1)CC1=NC(C2=CC=C(COC3=CC=C(C(CCC)CCC)C=C3)C=C2)=CS1
Formula:	C₃₄H₄₃N₃O₃S₂
M.Wt:	605.86
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

JTT-551 (JTT551, JTT 551) is a novel potent, selective inhibitor of protein tyrosine phosphatase 1B (PTP1B) with Ki of 0.22 uM, displays >45-fold and >136-fold selectivity over TCPTP, CD45 and LAR; JTT-551 exhibits clear selectivity against the other PTPs, increases the insulin-stimulated glucose uptake in L6 cells; enhances the IR phosphorylation of liver and reduces the glucose level in ob/ob mice , also shows a hypoglycaemic effect without an acceleration of body weight gain in db/db mice.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC11191	JTT-551 sodium	JTT-551 sodium (JTT551, JTT 551) is a novel potent, selective inhibitor of protein tyrosine phosphatase 1B (PTP1B) with Ki of 0.22 uM, displays >45-fold and >136-fold selectivity over TCPTP, CD45 and LAR.
DC11190	JTT-551	JTT-551 (JTT551, JTT 551) is a novel potent, selective inhibitor of protein tyrosine phosphatase 1B (PTP1B) with Ki of 0.22 uM, displays >45-fold and >136-fold selectivity over TCPTP, CD45 and LAR.