CZh226
Cat. No.: DC11199
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Chemical Structure
2196199-00-3
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Field of application
CZh226 hydrochloride (CZh-226) is a potent, selective inhibitor of p21-activated kinase 4 (PAK4) with Ki of 9 nM, displays 346-fold selectivity over PAK-1.
| Cas No.: |
2196199-00-3 |
| Chemical Name: |
(R)-(6-Chloro-4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)- quinazolin-2-yl)(3-methylpiperazin-1-yl)methanone |
| Synonyms: |
CZh-226;CZh 226 |
| SMILES: |
O=C(N1C[C@@H](C)NCC1)C2=NC3=CC=C(Cl)C=C3C(NC4=NNC(C5CC5)=C4)=N2 |
| Formula: |
C20H22ClN7O |
| M.Wt: |
411.894 |
| Purity: |
>98% |
| Sotrage: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
CZh226 hydrochloride (CZh-226) is a potent, selective inhibitor of p21-activated kinase 4 (PAK4) with Ki of 9 nM, displays 346-fold selectivity over PAK-1; also exhibits excellent kinase spectrum selectivity against a panel of 54 kinases (<80% inhibition at 0.1 uM); potently inhibits the migration and invasion of A549 tumor cells by regulating the PAK4-directed downstream signaling pathways in vitro; CZh226 (CZh-226) is a valuable research probe for the further biological investigation of group II PAKs. |
MSDS
COA
| LOT NO. |
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| 2018-0101 |
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