TAK-071
Cat. No.: DC11208
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Chemical Structure
1820812-16-5
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Field of application
TAK-071 is a novel, potent and highly selective muscarinic acetylcholine receptor 1 (M1R) positive allosteric modulator. EC50 of TAK-071 M1R agonist activities is 520 nM.
| Cas No.: |
1820812-16-5 |
| Chemical Name: |
4-fluoro-2-[(3S,4S)-4-hydroxytetrahydro-2H-pyran-3-yl]-5-methyl-6-[4-(1H-pyrazol-1-yl)benzyl]-2,3-dihydro-1H-isoindol-1-one |
| Synonyms: |
TAK071;TAK 071 |
| SMILES: |
C(=O)1C2=C(C(F)=C(C)C(CC3=CC=C(N4C=CC=N4)C=C3)=C2)CN1[C@H]1[C@H](O)CCOC1 |
| Formula: |
C24H24FN3O3 |
| M.Wt: |
421.472 |
| Purity: |
>98% |
| Sotrage: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
TAK-071 is a novel muscarinic acetylcholine receptor 1 (M1R) positive allosteric modulator. EC50 of TAK-071 M1R agonist activities is 520 nM[1]. |
| Target: |
EC50: 520 nM (M1R)[1] |
| References: |
[1]. Sako Y, et al. TAK-071, a novel M1 positive allosteric modulator with low cooperativity, improves cognitive function in rodents with few cholinergic side effects. Neuropsychopharmacology. 2018 Aug 1. doi: 10.1038/s41386-018-0168-8. |
MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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| 2018-0101 |
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