DS-8500a
Cat. No.: DC11233
Chemical Structure
1371591-51-3
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Field of application
DS-8500a (DS8500a) is a novel potent, selective, orally available GPR119 agonist with EC50 of 51.5 nM in human GPR119-expressing CHO-K1 cells, displays no significant effect on 66 receptors, channels, or transporters.
| Cas No.: |
1371591-51-3 |
| Chemical Name: |
4-(5-{(1R)-1-[4-(cyclopropylcarbonyl)phenoxy]propyl}-1,2,4-oxadiazol-3-yl)-2-fluoro-N-[(2R)-1-hydroxypropan-2-yl]benzamide |
| Synonyms: |
DS8500a;DS 8500a |
| SMILES: |
C(N[C@@H](C)CO)(=O)C1=CC=C(C2N=C([C@@H](OC3=CC=C(C(C4CC4)=O)C=C3)CC)ON=2)C=C1F |
| Formula: |
C25H26FN3O5 |
| M.Wt: |
467.497 |
| Purity: |
>98% |
| Sotrage: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
DS-8500a (DS8500a) is a novel potent, selective, orally available GPR119 agonist with EC50 of 51.5 nM in human GPR119-expressing CHO-K1 cells, displays no significant effect on 66 receptors, channels, or transporters; enhances glucose-stimulated insulin secretion in Sprague-Dawley rats and promotes GLP-1 secretion in Zucker fatty rats, preserved β cell function and prevented increases in glycohemoglobin concentrations in rodent models of type 2 diabetes. |
MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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