KDOAM-25|cas 2230731-99-2|DC Chemicals

Cas No.:	2230731-99-2
Chemical Name:	2-[[[2-[2-(Dimethylamino)ethyl-Ethyl-Amino]-2-Oxidanylidene-Ethyl]amino]methyl]pyridine-4-Carboxamide
Synonyms:	KDOAM25;2-[[[2-[2-(Dimethylamino)ethyl-Ethyl-Amino]-2-Oxidanylidene-Ethyl]amino]methyl]pyridine-4-Carboxamide;2-[[[2-[2-(dimethylamino)ethyl-ethylamino]-2-oxoethyl]amino]methyl]pyridine-4-carboxamide;LQT;KDOAM25A;KDOAM25;KDOAM 25;GTPL8576;BDBM223320;BCP31703;NSC785219;Q27462671
SMILES:	O=C(C([H])([H])N([H])C([H])([H])C1C([H])=C(C(N([H])[H])=O)C([H])=C([H])N=1)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
Formula:	C₁₅H₂₅N₅O₂
M.Wt:	307.3913
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

KDOAM-25 (KDM5 inhibitor KDOAM 25) is a potent, selective KDM5 sub-family(JARID1) inhibitor with biochemical IC50 of 71/19/69/69 nM for KDM5A/B/C/D, respectively; weakly inhibits KDM4C/KDM2B (IC50=4.8/4.4 uM) and good selectivity over other demethylases; most potently inhibits KDM5B (IC50=50 uM) and increases H3K4me3 levels in Hela cells; increases global H3K4 methylation, causes G1 cell-cycle arrest and impairs cell proliferation in multiple myeloma MM1S cells.

References:

References 1. Tumber A, et al. Cell Chem Biol. 2017 Mar 16;24(3):371-380. View Related Products by Target Histone Demethylase

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101
2018-0101

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