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PFI-90

  Cat. No.:  DC45562   Featured
Chemical Structure
53995-62-3
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More than 5000 active chemicals with high quality for research!
Field of application
PFI-90 is a selective inhibitor of the histone demethylase KDM3B. PFI-90 induces apoptosis and cell differentiation resulting in delayed tumor progression in vivo.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 53995-62-3
Chemical Name: 2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide
Synonyms: 2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide
SMILES: C1C=NC(=CC=1)NNC(=O)C2N=CC=CC=2
Formula: C11H10N4O
M.Wt: 214.223
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: PFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action. PFI-90 induces apoptosis and myogenic differentiation, resulting in the cell death increased. PFI-90 has the potential for the antitumor activity. (patent WO2021101929A1).
Target: IC50: 812 nM (RH4); 3200 nM (RH30); 1895 nM (OSA-CL); 1113 nM (TC-32)[1]
In Vitro: PFI-90 shows dose response in RH4, RH30, OSA-CL and TC-32 cells, with IC50s of 812, 3200, 1895 and 1113 nM, respectively[1]. PFI-90 (3 μΜ; 24 hours) increases apoptosis in RH4 and SCMC cells[1]. Western Blot Analysis[1] Cell Line: RH4 and SCMC cells Concentration: 3 μΜ Incubation Time: 24 hours Result: Apoptosis increased in RH4 and SCMC cells.
References: [1]. KHAN, Javed, et al. Inhibitors of histone demethylases (pfi-63 and pfi-90) for the treatment of cancer and for the inhibition of histone demethylase in cells. WO2021101929A1
MSDS
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Cat. No. Product name Field of application
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