Netazepide
Cat. No.: DC11550
Chemical Structure
155488-25-8
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Field of application
Netazepide (YF476, Sograzepide) is a potent, selective and orally active gastrin/CCK-2 antagonist with IC50 of 0.1 nM.
| Cas No.: |
155488-25-8 |
| Chemical Name: |
(R)-1-(1-(3,3-dimethyl-2-oxobutyl)-2-oxo-5-(pyridin-2-yl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-3-(3-(methylamino)phenyl)urea |
| Synonyms: |
YF476;YF-476;Sograzepide |
| SMILES: |
N([C@@H]1C(=O)N(CC(=O)C(C)(C)C)C2=CC=CC=C2C(C2=NC=CC=C2)=N1)C(NC1=CC=CC(NC)=C1)=O |
| Formula: |
C28H30N6O3 |
| M.Wt: |
498.587 |
| Purity: |
>98% |
| Sotrage: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
Netazepide (YF476, Sograzepide) is a potent, selective and orally active gastrin/CCK-2 antagonist with IC50 of 0.1 nM; displays >5,000-fold selectivity over CCK-1 receptors; inhibits pentagastrin-induced gastric acid secretion in anesthetized rats (ED50=87 nM/kg), and shows potential for the treatment of gastroesophageal reflux disease (GERD); also inhibits gastric neuroendocrine enterochromaffin-like (ECL) cell hyperplasia and gastric carcinoid tumor development. |
MSDS
COA
| LOT NO. |
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| 2018-0101 |
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