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E3 Ligase Ligand 2

  Cat. No.:  DC11565   Featured
Chemical Structure
5054-59-1
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More than 5000 active chemicals with high quality for research!
Field of application
E3 ligase Ligand 2 is a Ligand for E3 Ligase used in PROTAC technology.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 5054-59-1
Chemical Name: 2-(2,6-dioxopiperidin-3-yl)-4-hydroxyisoindoline-1,3-dione
SMILES: C(=O)1C2=C(C(O)=CC=C2)C(=O)N1C1CCC(=O)NC1=O
Formula: C13H10N2O5
M.Wt: 274.232
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: E3 ligase Ligand 2 is a Ligand for E3 Ligase used in PROTAC technology.
Target: Ligand for E3 Ligase[1]
In Vitro: Thalidomide may exert anti-angiogenic effect in isolated blood vessels and endothelial cells. E3 ligase Ligand 2 is a putative hydroxylated thalidomide metabolite. E3 ligase Ligand 2 has weak anti-angiogenic activity (14% mean inhibition of blood vessel density at 100 mg). E3 ligase Ligand 2 does not have any anti-proliferative effect against the breast or neuroblastoma cells, but do possess appreciable anti-proliferative activity against the endothelial cells[1].
References: [1]. Marks MG, et al. Effects of putative hydroxylated thalidomide metabolites on blood vessel density in the chorioallantoic membrane (CAM) assay and on tumor and endothelial cell proliferation. Biol Pharm Bull. 2002 May;25(5):597-604.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
Cat. No. Product name Field of application
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