RIPK2-IN-8 |

Cas No.:	2141969-56-2
Chemical Name:	4-(6-(tert-butylsulfonyl)-7-ethoxyimidazo[1,2-a]pyridin-3-yl)-6-fluoropyridin-2-amine
SMILES:	C(N)1=NC(F)=CC(C2N3C(=NC=2)C=C(OCC)C(S(C(C)(C)C)(=O)=O)=C3)=C1
Formula:	C₁₈H₂₁FN₄O₃S
M.Wt:	392.449
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A potent, selective, orally available RIPK2 inhibitor with IC50 of 3 nM; displays 90% percent of kinases showed <50% inhibition in a broad 250 kinase panel; effectively suppresses IL6 secrection in mouse bone marrow derived macrophages with IC50 of 12 nM; significantly reverses MDP-induced pro-inflammatory cytokines in rat colon.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC47267	RIP2 Kinase Inhibitor 4	RIP2 Kinase Inhibitor 4 is a potent and selective RIPK2 PROTAC. RIP2 Kinase Inhibitor 4 effectively degrades RIPK2 (pIC50 of 8) and inhibits the release of related TNF-α.
DC46825	GSK-872 hydrochloride	GSK-872 hydrochloride is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC50 of 1.8 nM, and inhibits kinase activity with an IC50 of 1.3 nM. GSK-872 hydrochloride decreases the RIPK3-mediated necroptosis and subsequent cytoplasmic translocation and expression of HMGB1, as well as ameliorates brain edema and neurological deficits in early brain injury.
DC46824	Eclitasertib	Eclitasertib (DNL-758) is a potent receptor-interacting protein kinase 1 (RIPK1) inhibitor with an IC50 of <1 µΜ (From patent WO2017136727A2, example 42).
DC44123	RIPK3-IN-1	RIPK3-IN-1 is a RIPK3 type II DFG-out inhibitor with an IC50 of 9.1 nM. RIPK3-IN-1 inhibits RIPK1 and RIPK2 with IC50s of 5.5 and >10 μM. RIPK3-IN-1 is also a c-Met kinase inhibitor with an IC50 of 1.1 μM.
DC28704	RIP2 kinase inhibitor 1	RIP2 kinase inhibitor 1 (compound 11) is a potent and selective receptor interacting protein 2 (RIP2) kinase inhibitor with an IC50 of 0.03 μM for RIP2 FP. RIP2 kinase inhibitor 1 is used for autoinflammatory disorders.
DC11620	RIPK2-IN-8	A potent, selective, orally available RIPK2 inhibitor with IC50 of 3 nM.