JNJ-2408068
Cat. No.: DC11647
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Chemical Structure
317846-22-3
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Field of application
JNJ 2408068 is a potent RSV (respiratory syncytial virus) inhibitor. JNJ2408068 significantly inhibits replication of RSV A and B subtypes in the lungs of cotton rats without any evidence of toxicity. The minimum protective dose of JNJ 2408068 appears to be approximately 0.39 mg/kg[1].
| Cas No.: |
317846-22-3 |
| Chemical Name: |
2[[2-[[1-(2-aminoethyl)-4-piperidinyl]amino]-4-methyl-1H-benzimidazol-1-yl]methyl]-6-methyl-3-pyridinol |
| Synonyms: |
R-170591;R170591;JNJ 2408068;JNJ2408068 |
| SMILES: |
C(CN1C(NC2CCN(CCN)CC2)=NC2=C(C)C=CC=C21)1=NC(C)=CC=C1O |
| Formula: |
C22H30N6O |
| M.Wt: |
394.523 |
| Purity: |
>98% |
| Sotrage: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Publication: |
[1]. Wyde PR, et al. Short duration aerosols of JNJ 2408068 (R170591) administered prophylactically or therapeutically protect cotton rats from experimental respiratory syncytial virus infection. Antiviral Res. 2003 Nov;60(3):221-31. |
| Description: |
JNJ 2408068 is a potent RSV (respiratory syncytial virus) inhibitor. JNJ 2408068 significantly inhibits replication of RSV A and B subtypes in the lungs of cotton rats without any evidence of toxicity. The minimum protective dose of JNJ 2408068 appears to be approximately 0.39 mg/kg[1]. |
| Target: |
RSV-A
RSV-B |
| References: |
[1]. Wyde PR, et al. Short duration aerosols of JNJ 2408068 (R170591) administered prophylactically or therapeutically protect cotton rats from experimental respiratory syncytial virus infection. Antiviral Res. 2003 Nov;60(3):221-31. |
MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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| 2018-0101 |
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