HLY-78
Cat. No.: DC11651
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Chemical Structure
854847-61-3
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Field of application
HLY78 is an activator of the Wnt/β-catenin signaling pathway, which targets the DIX domain of Axin and potentiates the Axin-LRP6 association to promote Wnt signaling transduction[1].
| Cas No.: |
854847-61-3 |
| Chemical Name: |
4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine |
| Synonyms: |
HLY78;HLY 78 |
| SMILES: |
C1=C2C(N(C)CC3=C2C=C2OCOC2=C3)=C(CC)C=C1 |
| Formula: |
C17H17NO2 |
| M.Wt: |
267.3 |
| Purity: |
>98% |
| Sotrage: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
An activator of the Wnt/β-catenin signaling pathway that targets the DIX domain of Axin; potentiates the Axin-LRP6 association, thus promoting LRP6 phosphorylation and Wnt signaling transduction; acts synergistically with Wnt in the embryonic development of zebrafish and increases the expression of the conserved hematopoietic stem cell (HSC) markers, runx1 and cmyb, in zebrafish embryos. |
| Target: |
Wnt/β-catenin[1] |
| References: |
[1]. Wang S, et al. Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction. Nat Chem Biol. 2013 Sep;9(9):579-85. |
MSDS
COA
| LOT NO. |
DOWNLOAD |
|
|
| 2018-0101 |
|
| 2018-0101 |
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