PF-00446687 hydrochloride|PF-446687;PF00446687

Cas No.:	862282-10-8
Chemical Name:	(3R,4R,5S)-1-{[(3S,4R)-1-tert-Butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]carbonyl}-3,5-dimethyl-4-phenylpiperidin-4-ol hydrochloride
Synonyms:	PF-446687;PF00446687
SMILES:	N(C([C@@H]1[C@@H](C2=CC=C(F)C=C2F)CN(C(C)(C)C)C1)=O)1C[C@@H](C)[C@](C2=CC=CC=C2)(O)[C@@H](C)C1.[H]Cl
Formula:	C₂₈H₃₇ClF₂N₂O₂
M.Wt:	507.06
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

PF-00446687 hydrochloride (PF-446687) is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 nM; displays >100-fold selectivity over MC1R/1 uM); is find to be active in preliminary human trials, with the 200mg dose being of similar effectiveness to 100mg sildenafil, though lower doses were ineffective.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC11665	PF-00446687	PF-00446687(PF-446687) is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 nM.
DC11664	PF-00446687 hydrochloride	PF-00446687 hydrochloride (PF-446687) is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 nM.