CFI-401870|CFI401870;CFI 401870

Cas No.:	1599460-95-3
Chemical Name:	N-((R)-cyclopropyl(pyridin-2-yl)methyl)-3-(4-((1R,3R,5S)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl)phenyl)-1H-indazole-5-carboxamide
Synonyms:	CFI401870;CFI 401870
SMILES:	N1C2=C(C=C(C(N[C@@H](C3CC3)C3=NC=CC=C3)=O)C=C2)C(C2=CC=C(N3[C@@]([H])4CC[C@@]3([H])C[C@@H](O)C4)C=C2)=N1
Formula:	C₃₀H₃₁N₅O₂
M.Wt:	493.611
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A potent, selective, orally active Mps1 (TTK) inhibitor with IC50 of 3.1 nM; displays low off-target activity (>500-fold) and microsomal stability; inhibits HCT116 cell growth with GI50 of <0.1 uM, demonstrates in vivo tumor growth inhibition.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC28264	TC-Mps1-12	TC-Mps1-12 is a potent and selective monopolar spindle 1 (Mps1) inhibitor, with an IC50 of 6.4 nM.
DC5087	Mps1-IN-1	Mps1-IN-1 is a highly potent and selectibe Mpsl inhibitor with IC50 of 367 nM; >1000-fold selectivity relative to the 352 member kinase panel with the major exceptions of Alk and Ltk.
DC11677	CCT-271850	A potent, selective, orally bioavailable Mps1 kinase inhibitor with IC50 of 11 nM.
DC11704	CFI-401870	A potent, selective, orally active Mps1 (TTK) inhibitor with IC50 of 3.1 nM.