Cas No.: | 1611470-23-5 |
Chemical Name: | 5-(3, 5-dimethoxybenzyloxy)-3-indoleacetic acid |
Synonyms: | MA-35;MA35;MA 35 |
SMILES: | N1C2=C(C=C(OCC3=CC(OC)=CC(OC)=C3)C=C2)C(CC(O)=O)=C1 |
Formula: | C19H19NO5 |
M.Wt: | 341.36 |
Purity: | >98% |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | A dual inhibitor of TNF-α and TGF-β1 by inhibiting IκB kinase phosphorylation and Smad3 phosphorylation; attenuates the LPS/GaIN-induced hepatic inflammation in the mice, and downregulates TGF-β1-induced fibrotic gene expression; attenuates renal inflammation and fibrosis with the downregulation of inflammatory cytokines and fibrotic gene expressions in renal fibrosis model. |