Mitochonic Acid 35

  Cat. No.:  DC11708  
Chemical Structure
1611470-23-5
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More than 5000 active chemicals with high quality for research!
Field of application
A dual inhibitor of TNF-α and TGF-β1 by inhibiting IκB kinase phosphorylation and Smad3 phosphorylation.
Cas No.: 1611470-23-5
Chemical Name: 5-(3, 5-dimethoxybenzyloxy)-3-indoleacetic acid
Synonyms: MA-35;MA35;MA 35
SMILES: N1C2=C(C=C(OCC3=CC(OC)=CC(OC)=C3)C=C2)C(CC(O)=O)=C1
Formula: C19H19NO5
M.Wt: 341.36
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: A dual inhibitor of TNF-α and TGF-β1 by inhibiting IκB kinase phosphorylation and Smad3 phosphorylation; attenuates the LPS/GaIN-induced hepatic inflammation in the mice, and downregulates TGF-β1-induced fibrotic gene expression; attenuates renal inflammation and fibrosis with the downregulation of inflammatory cytokines and fibrotic gene expressions in renal fibrosis model.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC10419 C 87 C87 is a novel small-molecule TNFα inhibitor; potently inhibits TNFα-induced cytotoxicity with an IC50 of 8.73 μM.
DC11708 Mitochonic Acid 35 A dual inhibitor of TNF-α and TGF-β1 by inhibiting IκB kinase phosphorylation and Smad3 phosphorylation.
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