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| Cas No.: | 2095732-06-0 |
| Chemical Name: | (3R,4S)-1-(L-alanyl)-3-amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic acid |
| Synonyms: | INCB-01158;INCB01158;CB 1158 |
| SMILES: | O=C([C@@H](N)C)N1C[C@H](CCCB(O)O)[C@](N)(C(O)=O)C1 |
| Formula: | C11H22BN3O5 |
| M.Wt: | 287.12 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | CB-1158 (INCB-01158) is a potent, selective, oral available Arginase inhibitor with IC50 of 98 nM; reduces tumor growth, increases the number of tumor infiltrating CD8+ T-cells, and increases the level of Th1/NK/M1-associated chemokines, cytokines, and activation markers in the tumor microenvironment in combination with checkpoint inhibitors in mice bearing LLC tumors; a novel immuno-oncology agent targeting the immunosuppressive effects of tumor-infiltrating myeloid cells; high oral bioavailability. |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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