ABP-A3|ABP A3

Cas No.:
Chemical Name:	((2R,3S,4R,5R)-5-(6-((4-ethynylphenyl)amino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl sulfamate
Synonyms:	ABP A3
SMILES:	S(N)(OC[C@H]1[C@H](O)[C@H](O)[C@@H](N2C3C(N=C2)=C(NC2=CC=C(C#C)C=C2)N=CN=3)O1)(=O)=O
Formula:	C₁₈H₁₈N₆O₆S
M.Wt:	446.438
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

ABP-A3(ABP A3) is an inhibitor of ubiquitin conjugation that targets ubiquitin and Nedd8 E1 enzymes; inhibits conjugation of ubiquitin to intracellular proteins and prevents the formation of cytoprotective aggresomes; induces activation of the unfolded protein response (UPR) and apoptosis, displays IC50 of 2.5 uM in cell viability assays in A549 cells.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC28777	Ubiquitination-IN-1	Ubiquitination-IN-1 (compound 24) is a ubiquitination and Cksl-Skp2 protein-protein interaction (IC50=0.17 μM) inhibitor. Ubiquitination-IN-1 increases levels of p27. Ubiquitination-IN-1 has the potential for treatment disease by blocking the degradation of tumor suppressors.
DC9430	PYZD-4409	PYZD-4409 is a novel small molecule inhibitor of Ubiquitin-activating enzyme UBA1/E1 enzyme with an IC50 of 20 uM (cell-free enzymatic assay).
DC11762	ABP-A3	ABP-A3(ABP A3) is an inhibitor of ubiquitin conjugation that targets ubiquitin and Nedd8 E1 enzymes.
DC11766	UbcH5c-IN-6d	A potent, specific, orally bioactive small-molecule inhibitor of ubiquitin-conjugating enzyme UbcH5c with Kd of 283 nM.
DC11767	IJ-5	A potent, covalent inhibitor of ubiquitin-conjugating enzyme UbcH5 with Kd of 5.189 uM, 3.578 uM, and 2.577 uM for UbcH5a, UbcH5b, and UbcH5c, respectively.
DC11763	ABP 1	A nonselective inhibitor of UBL protein-activating E1 enzymes that forms covalent adducts with UBL proteins SUMO1, ubiquitin, Nedd8, ISG15, and GABARAP in the presence of ATP and E1 enzymes in vitro.