APX-115
Cat. No.: DC11809
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Chemical Structure
1270084-92-8
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Field of application
APX-115 (Ewha 18278) is a first-in-class, orally active, pan-NADPH oxidase (Nox) inhibitor with Ki of 1.08, 0.57, 0.63 nM for Nox1, Nox2, and Nox4, respectively.
| Cas No.: |
1270084-92-8 |
| Chemical Name: |
3-phenyl-1-(pyridin-2-yl)-4-propyl-1-5-hydroxypyrazol |
| Synonyms: |
Ewha 18278;APX 115;APX511;Ewha-18278;Ewha18278 |
| SMILES: |
CCCC1=C(NN(C1=O)C2=CC=CC=N2)C3=CC=CC=C3 |
| Purity: |
>98% |
| Sotrage: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base effectively prevents kidney injury[1]. |
| Target: |
Ki: 1.08 μM (Nox1), 0.57 μM (Nox2) and 0.63 μM (Nox4)[1] |
| References: |
[1]. Kwon G, et al. A novel pan-Nox inhibitor, APX-115, protects kidney injury in streptozotocin-induced diabetic mice: possible role of peroxisomal and mitochondrial biogenesis. Oncotarget. 2017 Jun 16;8(43):74217-74232. |
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