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| Cas No.: | 1270084-92-8 |
| Chemical Name: | Isuzinaxib |
| Synonyms: | Ewha 18278;APX 115;APX511;Ewha-18278;Ewha18278 |
| SMILES: | CCCC1=C(NN(C1=O)C2=CC=CC=N2)C3=CC=CC=C3 |
| Formula: | C17H17N3O |
| M.Wt: | 279.343 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base effectively prevents kidney injury[1]. |
| Target: | Ki: 1.08 μM (Nox1), 0.57 μM (Nox2) and 0.63 μM (Nox4)[1] |
| References: | [1]. Kwon G, et al. A novel pan-Nox inhibitor, APX-115, protects kidney injury in streptozotocin-induced diabetic mice: possible role of peroxisomal and mitochondrial biogenesis. Oncotarget. 2017 Jun 16;8(43):74217-74232. |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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| 2018-0101 |
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| 2018-0101 |
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