DC Chemicals' products qualify for U.S. tariff exemptions. We guarantee no price increases due to customs duties and maintain stable supply, continuing to deliver reliable research solutions to our American clients.
| Cas No.: | 1255204-84-2 |
| Chemical Name: | 5,5'-{piperazine-1,4-diylbis[(1R)-1-hydroxyethane-2,1-diyl]}bis(4-methyl-2-benzofuran-1(3H)-one) |
| Synonyms: | MK 7145;MK7145 |
| SMILES: | N(C[C@H](C1=CC=C2C(=C1C)COC2=O)O)1CCN(C[C@H](C2=CC=C3C(=C2C)COC3=O)O)CC1 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | A potent, selective, and oral renal outer medullary potassium channel (ROMK) inhibitor with IC50 of 68 nM; shows no significant activity on Kir family of channels and cardiac ion channels such as Cav1.2 and Nav1.5 (IC50>30 uM); evokes remarkable diuresis and natriuresis in the acute rat diuresis model at 0.3 mg/kg, causes dose-dependent lowering of blood pressure in a subchronic SHR model. |
MSDS
COA
| LOT NO. | DOWNLOAD |
|
|
|
| 2018-0101 |
|