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| Cas No.: | 1186231-83-3 |
| Chemical Name: | 6-Ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-3-(2,2,2-trifluoroethoxy)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide |
| Synonyms: | TAK 441;TAK441 |
| SMILES: | C(=O)1N(CC(=O)C2=CC=CC=C2)C(CC)=CC2N(C)C(C(NC3CCN(C(CO)=O)CC3)=O)=C(OCC(F)(F)F)C1=2 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | A highly potent, orally active hedgehog signaling (Hh) inhibitor with IC50 of 4.4 nM in Gli-luc reporter assays; suppresses transcription factor Gli1 mRNA expression in tumor-associated stromal tissue and inhibits tumor growth in mouse medulloblastoma allograft model. |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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