Foliglurax hydrochloride

  Cat. No.:  DC11895  
Chemical Structure
2133294-96-7
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More than 5000 active chemicals with high quality for research!
Field of application
A potent, selective, brain-penetrant and orally bioavailable mGluR4 positive allosteric modulator with EC50 of 79 nM.
Cas No.: 2133294-96-7
Chemical Name: (E)-6-(3-morpholinopropyl)-2-(thieno[3,2-c]pyridin-6-yl)-4H-chromen-4-one oxime hydrochloride
Synonyms: PXT 002331;PXT002331
SMILES: C(C1N=CC2C=CSC=2C=1)1OC2=C(C=C(CCCN3CCOCC3)C=C2)/C(=N/O)/C=1.[H]Cl
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: A potent, selective, brain-penetrant and orally bioavailable mGluR4 positive allosteric modulator with EC50 of 79 nM; shows more than 15-, 110- and 50-times higher selectivity for mGluR4 than for mGluR6, -7, and -8, respectively, no effect on NMDA, AMPA, kainate, group I or group II mGluRs, COMT, MAO-A or MAO-B (IC50>10 uM); demonstrates significant antiparkinsonian activity in rodent models of PD motor symptoms
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC11894 Foliglurax A potent, selective, brain-penetrant and orally bioavailable mGluR4 positive allosteric modulator with EC50 of 79 nM.
DC11895 Foliglurax hydrochloride A potent, selective, brain-penetrant and orally bioavailable mGluR4 positive allosteric modulator with EC50 of 79 nM.
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