| Cas No.: | 2133294-96-7 |
| Chemical Name: | (E)-6-(3-morpholinopropyl)-2-(thieno[3,2-c]pyridin-6-yl)-4H-chromen-4-one oxime hydrochloride |
| Synonyms: | PXT 002331;PXT002331 |
| SMILES: | C(C1N=CC2C=CSC=2C=1)1OC2=C(C=C(CCCN3CCOCC3)C=C2)/C(=N/O)/C=1.[H]Cl |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | A potent, selective, brain-penetrant and orally bioavailable mGluR4 positive allosteric modulator with EC50 of 79 nM; shows more than 15-, 110- and 50-times higher selectivity for mGluR4 than for mGluR6, -7, and -8, respectively, no effect on NMDA, AMPA, kainate, group I or group II mGluRs, COMT, MAO-A or MAO-B (IC50>10 uM); demonstrates significant antiparkinsonian activity in rodent models of PD motor symptoms |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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