Cas No.: | 1374524-68-1 |
Chemical Name: | (3R,4S)-3,4-bis(4-hydroxyphenyl)-8-methyl-3,4-dihydro-2H-chromen-7-ol |
Synonyms: | ME344;ME 344;NV-344 |
SMILES: | C1OC2=C(C=CC(O)=C2C)[C@@H](C2=CC=C(O)C=C2)[C@H]1C1=CC=C(O)C=C1 |
Purity: | >98% |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | A novel mitochondrial and mTOR inhibitor with potent anti-cancer activity, inhibits leukemia cell lines with IC50 of 70-260 nM; inhibits oxygen consumption rates, with specific effects on the respiratory chain, causes complex, redox-specific, and mitochondria-targeted effects in lung cancer cells; reduces tumor growth in OCI-AML2 xenograft model; an active metabolite of NV-128. |